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1-Hexanol CAS 111-27-3 | Look Chemical
Table of 1-Hexanol
1-Hexanol
Basic Info
| Product Name: | 1-Hexanol |
| Synonyms: | n-Hexanol; n-Hexyl alcohol; Hexyl Alcohol |
| CAS: | 111-27-3 |
| MF: | C6H14O |
| MW: | 102.17 |
| EINECS: | 203-852-3 |
| Product Categories: | Food additives; Flavors and fragrances |
Chemical Properties
Melting point | -52 °C (lit.) |
Boiling point | 156-157 °C (lit.) |
density | 0.814 g/mL at 25 °C (lit.) |
vapor density | 4.5 (vs air) |
vapor pressure | 1 mm Hg ( 25.6 °C) |
refractive index | n20/D 1.418(lit.) |
Fp | 140 °F |
storage temp. | no restrictions. |
solubility | ethanol: soluble(lit.) |
pka | 15.38±0.10(Predicted) |
form | Liquid |
color | Clear colorless |
What is 1-Hexanol?
Colorless liquid. Boiling point 157℃, relative density 0.819, miscible with ethanol, propylene glycol, and oil. It has a light green scent of young branches and leaves, with a slight aroma of wine, fruit and fat. Hexanol or its carboxylic acid esters are present in trace amounts in citrus, berries, etc. Tea, geranium oil, various lavender oils, bananas, apples, strawberries, violet leaf oils and other essential oils also contain it.
1-Hexanol can react with some oxidants, such as acidic potassium permanganate, acidic chromium dioxide, etc. In addition, hexanol can also undergo esterification, etherification, dehydration, etc.
1-Hexanol has a certain degree of toxicity, and long-term contact or inhalation may cause damage to the human body, such as irritation to the eyes, skin and respiratory tract. Therefore, it is necessary to pay attention to protective measures when using it, such as wearing gloves and masks.
1-Hexanol Uses
Gas chromatography analysis standard. Separation of lithium chloride from potassium chloride and sodium chloride. Solvent.
1-Hexanol has been used as an odorant to study olfactory responses and to thin dielectric layers of poly(4-vinylphenol) (PVP).
1-Hexanol is considered as a perturbator of actomyosin ATPase and is found to modulate the function of actomyosin motors through intermediate-specific structural perturbations.
1-Hexanol can be used as a precursor of plasticizers, an intermediate in pharmaceutical chemistry, a fragrance ester, and a preservative. In addition, it can act as a perturbator of actomyosin ATPase. In addition, it is used to modulate the function of actomyosin motors.
Used in the synthesis of spices and the preparation of hexanoic acid; also used as a gas chromatography reagent for Wittig reaction and Aldol reaction.
It is often used as a part of the top note in the base of flavors and in the preparation of essential oils (such as geranium oil). Trace amounts of hexanol are used to modify or add a tender atmosphere to violet, osmanthus, magnolia, and ylang-ylang flavors, and are also used in edible coconut, berry, and various fruit flavors. It is used as a solvent and analytical reagent, and as a preservative and sleeping pill in the pharmaceutical industry. This product is listed in China GB 2760-96. It is mainly used to prepare coconut and berry flavors, and is also used in the production of surfactants, plasticizers, fatty alcohols, etc. It is also used as a chromatographic reagent and organic synthesis.
Applications of 1-Hexanol
1-Hexanol is used as a part of the top note in flavor base and preparation of essential oils (such as geranium oil). It can also be used in trace amounts in violet, osmanthus, magnolia, and ylang-ylang flavors to modify or increase the green and tender smell. It can also be used in trace amounts in edible coconut formulas, berries, and various fruit flavors; used as solvents and analytical reagents, and also used in the pharmaceutical industry to make preservatives and sleeping pills. This product is a permitted edible flavoring in my country’s GB2760-86 regulations. It is mainly used to prepare coconut and berry flavors; used in the production of surfactants, plasticizers, fatty alcohols, etc.; used as a chromatographic analysis reagent, and also used in organic synthesis, etc.
1-Hexanol is a commonly used solvent and is used in many fields. For example, in the production of chemicals, n-hexanol is an important chemical raw material that can be used to produce chemicals such as aldehydes, acids, esters, polyesters, and polyurethanes. 1-Hexanol is widely used in drug manufacturing and can be used as an intermediate, solvent, diluent, etc. For example, it can be used to prepare drugs such as tropisetron, bezafibrate, and triazone. In addition, the compound can also be used as a diluent, cleaning agent, emulsifier, etc. in paints and coatings to improve the performance and quality of the coating. In pesticide production, n-hexanol can be used to produce pesticides and insecticides. In addition to the above application areas, n-hexanol can also be used in fuel cells, fine chemicals manufacturing, dye manufacturing, food additives, etc.
References
1-Hexanol – WikiPedia
Das, Pranab J. et al Asian Journal of Chemistry, 30(3), 651-654; 2018