Name: Poloxamer 188
Cas: 9003-11-6
Purity: 99%
MOQ: 1KG
Directory Guidance on Poloxamer 188
Chemical Structure
Basic Info
Poloxamer 188 is a polymer with numerous industrial applications. Right here is a short introduction to its residential properties, makes use of, making approaches, and safety and security details:
The buildings of Poloxamer 188:
1. Chemical framework: Poloxamer 188 is a copolymer of polyvinyl alcohol (PEG) and polypropylene glycol (PPG), with a molecular weight normally ranging from thousands to tens of thousands.
2. Look: Generally white powder with great flowability.
3. Solubility: It can dissolve well in water and additionally has some solubility in polar solvents and specific oils.
4. Surfactant properties: Poloxamer 188 has outstanding emulsifying, moistening, and dispersing buildings.
5. Temperature level of sensitivity: Under particular conditions, especially at various temperature levels and concentrations, it can show different physical and chemical properties.
Making use of Poloxamer 188:
Biotechnology: Poloxamer 188 is made use of as a non-ionic surfactant in biotechnology areas such as cell culture and genetics transfer.
Poloxamer 188 is a common polymer pharmaceutical excipient, which is a non-ionic surfactant with outstanding emulsifying capacity and safety and security. Due to its ability to stabilize cell membrane structural defects caused by numerous reasons, Poloxamer 188 has actually received extensive attention.
The production method of Poloxamer 188:
Poloxamer 188 is usually prepared with polymerization responses. The specific techniques consist of:
1. Aggregation response: The copolymerization of epoxy substances (such as ethylene oxide and propylene oxide) in the presence of a catalyst is performed to prepare polymers of the preferred molecular weight.
2. Post processing: After splitting up, drying out, and squashing processes, the last Poloxamer 188 is obtained.
3. Quality assurance: The product goes through strict quality screening to ensure that its efficiency fulfills application standards.
Product Introduction
| Polyethylene-polypropylene glycol Chemical Properties |
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH Range | 5.0 – 7.5 |
| PH | 5.0-7.5 (100g/L in H2O) |
Product Nature
Specification
Product Nature
Product name | Poloxamer 188 |
Other name | Polyethylene-polypropylene glycol |
CAS No | 9003-11-6 |
EINECS No | 611-024-1/618-355-0/923-642-1 |
Appearance | White or yellowish translucent solid |
Molecular Formula | C5H10O2 |
Boiling point | 32.9ºC at 760 mmHg |
Melting point | 60-50ºC |
Flash point | 55.2ºC |
Molecular Weight | 102.13200 |
Purity | 99% |
Color | White or yellowish translucent |
Form | solid |
Specification
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 – 7.5 |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 | |
| Merck | 137,644 |
| LogP | -1.293 (est) |
| EPA Substance Registry System | Poloxalene (9003-11-6) |
Product Packaging
Poloxamer 188， Also known as Prosammer 188 or polyoxyethylene polyoxypropylene block copolymer, it is a surfactant and emulsifier widely used in various fields due to its unique physical and chemical properties. The following are the main uses of Poloxamer 188:
1. Pharmaceutical field
Pharmaceutical preparations:
Poloxamer 188 can be used as a dissolution aid and emulsifier for drugs, improving their solubility and bioavailability.
Poloxamer 188 is used as a stabilizer in injections to prevent degradation of active ingredients.
Slow release system:
Applied to sustained-release drug formulations, regulating the release rate of drugs.
Cell protection:
Poloxamer 188 is used to reduce tissue damage, such as protecting cell membrane integrity in the treatment of myocardial infarction or brain injury.
Protein protectants:
Protect protein drugs from physical conditions such as heat and mechanical shear damage.
2. Cosmetics and personal care products
Emulsifiers and thickeners:
Poloxamer 188 is used in face cream, lotion and facial cleaning products to improve texture and provide a sense of lubrication.
Cleaning agent:
Poloxamer 188 acts as a mild surfactant in shampoo and shower gel, reducing irritation to the skin.
3. Food industry
Emulsifiers and stabilizers:
Used for food emulsification and stabilization, such as ice cream, salad dressings, etc., to enhance texture and taste.
4. Industrial applications
Coatings and inks:
Poloxamer 188 is used as a dispersant to improve the dispersibility of pigments, enhance the uniformity and durability of coatings.
Textile industry:
In textile processing, Poloxamer 188 is used as a wetting and dispersing agent to enhance dyeing uniformity.
Lubrication and coolant:
Used in metalworking fluids to reduce friction and enhance cooling effectiveness.
5. Biotechnology and Research
Cell culture:
In biological research, it is used to protect the vitality of cells during freezing and thawing processes.
Drug delivery system:
Applied to carriers such as nanoparticles and microspheres to assist in targeted drug delivery.
6. Environmental Protection and Water Treatment
Wastewater treatment:
Used as a dispersant or co solvent in water treatment processes to enhance treatment efficiency.
Product advantages
Good biocompatibility: Poloxamer 188 has low irritation to human tissues and is suitable for pharmaceutical and cosmetic applications.
Strong thermal stability: can maintain stable performance over a wide temperature range.
Multifunctionality: Poloxamer 188 has various characteristics such as emulsification, solubilization, dispersion, wetting, etc., and is widely used.
Poloxamer 188 occupies an important position in high-end pharmaceuticals, cosmetics, and industrial fields due to its unique block copolymer structure, and is an indispensable functional additive.
Related References
Wikipedia-Poloxamer 188
Manufacturer of Poloxamer 188
Achievements
Service
FAQ
Advice on Shipping
Achievements
China Lookchemical is based in Shandong, serves the whole country, faces the world, and is determined to become an excellent supplier and service provider in the chemical industry.
As a top manufacturer of surfactant,cosmetic raw materials, disinfectants, flavors, and fragrances in China, we are committed to producing high-quality products and have won high praise from customers all over the world.
In the next 10 years or even longer, Lookchemical will always adhere to the tenet of quality first and reputation first, and devote itself to providing customers with thoughtful and perfect services.
As a professional Poloxamer 188 manufacturer, Look Chemical has served more than 6,000 customers around the world. Because of our high-quality products and professional services, we have won high praise from most of our customers.
Service
Pre-Sales Service
*The company cooperates with research institutes. We strictly control the process of raw materials up to the finished product.
*Dedicated to serving customers first, we provide reasonable prices, high quality products and timely delivery and follow-up services.
* Timely reply and 24 hours online, the professional team will provide you with the most favorable prices and high-quality products.
* The sample supports testing and inspection.
* Each batch of products will be tested to ensure that its quality meets user needs.
*Packaging can also be made according to customer requirements.
*Any inquiries will be answered by our relevant personnel within 24 hours.
*We will provide you with commercial invoice, packing list, packing list, COA, health certificate and certificate of origin if you need it. If your market has other special requirements, please let us know.
After-Sales Service
*We will monitor the logistics information in real time and will share the information with you.
* You can consult us at any time if you have any questions about the product, and we will answer you in time.
*If you have any questions about the product, you can report it to us, we will deal with it in time for you, and the product can be returned.
FAQ
To ensure the convenience of clients,we always set accurate reply for crucial question.Clients will get answer by inputting “keywords”to help clients solve relevant questions.
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
HOW TO CONFIRM WHETHER THE PRODUCT QUALITY MEETS OUR NEEDS BEFORE PLACING AN ORDER?
You can consult us to get free samples of some products, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us the product specifications and requirements you need, and we will manufacture products according to your requirements.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
LEARN MORE ABOUT US
Shandong Look Chemical
Advice on Shipping
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
Company Info
China Lookchemical is a professional enterprise that integrates research and development, production, and sales of new chemicals. The company was the first to specialize in providing organic intermediates. After several years of continuous efforts, especially in the fields of surfactants, feed additives, plant extracts, pesticides, industrial chemicals, etc., significant breakthroughs have been made.
The company adheres to the concept of “integrity management, strict quality control, customer first” and has received unanimous praise from customers at home and abroad.
At the same time, we can also provide customers with excellent transportation services. Adhere to customer centricity and integrity as the source of development, and gradually improve the company’s various systems. We are high-quality management personnel who have been engaged in chemical trade for many years, with a modern market management philosophy, and constantly explore customer market demands using flexible methods.
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